Tomlin (0-3, 9.24 ERA), who previously faced Chicago at home in a 9-3 Tribe loss during Game 6 of the 2016 World Series, allowed five runs on five hits including four home runs in 3 2/3 innings. It was the second outing this season in which Tomlin allowed four home runs.
In three starts this season, Tomlin has lasted into the fifth inning just once, and has allowed more home runs (8) than he's recorded strikeouts (7).
Cubs designated hitter Kyle Schwarber belted a pair of solo home runs against Tomlin, continuing his torrid hitting pace at Progressive Field. In seven career games at Cleveland (including postseason), Schwarber is hitting .517 (15-for-30) with a double, triple, three home runs and eight RBIs.
Tomlin exited in the fourth inning after serving up home runs to Schwarber and Ian Happ. He was followed by Dan Otero, Tyler Olson, Zach McAllister, Nick Goody and Matt Belisle out of the bullpen. McAllister surrendered three runs on three Cubs hits in the seventh, while Belisle allowed a pair of runs in the ninth.
Meanwhile, Cubs starter Tyler Chatwood (1-3, 3.74) held the Indians to a run on four hits in six innings to earn his first win of the season. Jose Ramirez collected three hits for the Tribe, including a double in the eighth inning. Bradley Zimmer picked up his second three-hit game of the season.
The Indians were 3-for-9 with runners in scoring position, but only scored two runs as Rajai Davis was called out at home plate in the third inning. Davis tried to score from second base on a Ramirez single to right field, but Cubs outfielder Jason Hayward threw to Wilson Contreras, who tagged the diving Davis on the rear end before he touched the plate.
Remembering 'The Sax Man'
The Indians paid tribute to longtime Cleveland saxophonist Maurice "The Sax Man" Reedus Jr., who died April 16 at age 65.
Reedus entertained downtown Cleveland sports fans and theater patrons with crowd-pleasing numbers for years.
As fans rose for Tuesday's seventh-inning stretch, the left field scoreboard played a video tribute of Reedus on stage performing his signature "Take Me Out to the Ballgame."
What it means
The Indians have dropped four consecutive games to the Cubs at Progressive Field by a combined score of 22-11 dating back to Game 2 of the 2016 World Series.
Tomlin threw 61 pitches, 40 (65 percent) for strikes. Chatwood threw 92 pitches, 49 (53 percent) for strikes.
Rain or shine
The Indians and Cubs drew 16,408 rain-soaked fans to Progressive Field on Tuesday. First pitch was at 6:10 p.m. with a temperature of 56 degrees. A light rain fell throughout the contest.
TV/radio: SportsTime Ohio and ESPN will broadcast tonight's game vs. the Cubs. WMMS/FM 100.7 will air the game.
Pitching matchups: LHP Jon Lester (2-0, 3.10) vs. RHP Trevor Bauer (1-2, 2.67).
Series: The Cubs are 10-9 in regular season play vs. the Indians.
Head-to-head: Bauer is 1-0 with seven scoreless innings in his only regular season start against the Cubs. Kris Bryant is hitting .429 (3-for-7) with one homer against him. Lester is 7-1 with a 3.03 ERA in 15 starts against the Indians. Rajai Davis is hitting .303 (15-for-53) with one homer and six RBI against him.
Team updates: This series is the first time the Indians and Cubs have played, outside of spring training, since the 2016 World Series. The Indians have won eight of their last 11 games and are coming off a 4-2 trip to Puerto Rico and Baltimore. The Cubs are 5-5 in their last 10.
Disabled list: Cubs — RHP Eddie Butler (right groin), LHP Drew Smyly (left elbow) and 2B Ben Zobrist (back) are on the disabled list. 3B Bryant (hit in head with pitch on Sunday) is day to day. Indians — OF Lonnie Chisenhall (right calf), INF Giovanny Urshela (right hamstring), LHP Ryan Merritt (left shoulder), RHP Danny Salazar (right shoulder) and RHP Cody Anderson (right elbow) are on the disabled list.
Next: Seattle visits for a four-game series starting Thursday.